Advancements of NMN Human Trials

Due to the popularity of NMN, there are many human clinical trials being conducted at the moment. Here are some key highlights:

• Throughout NMN human trials from the past three years, the NAD+ precursor hasn’t triggered any adverse physiological effects, confirming its safety.
• Human trials show NMN’s beneficial effects of enhancing insulin sensitivity and increasing physical capacity in aged adults.

Nicotinamide mononucleotide (NMN) serves as a precursor for nicotinamide adenine dinucleotide (NAD+), a crucial molecule involved in cellular repair and protection. However, the FDA banned NMN sales as a dietary supplement in 2022, despite initial approval for one company. This decision has raised questions about NMN’s safety and efficacy. While human trials suggest some anti-aging benefits, more research is needed.

NMN Is Safe and Enhances Physical Function and Metabolism of Aged Adults

Nicotinamide Mononucleotide (NMN) and NAD+: A Brief Overview

• NMN is a precursor for nicotinamide adenine dinucleotide (NAD+), a vital molecule involved in cellular repair, metabolism, and overall well-being.
• As we age, NAD+ levels decline, leading researchers to explore ways to boost NAD+ using NMN.

Safety and Efficacy of NMN in Humans: What the Studies Say

1. Keio University Study (2016): Male participants consumed 100, 250, or 500 mg of NMN in the morning. No harmful effects were observed, and the researchers concluded that up to 500 mg of NMN is safe and well-tolerated.
2. Harvard Study: Administered the highest NMN oral dose (1,000 mg twice daily for 14 days) with no adverse side effects.
3. Positive Effects on Physical Performance:
   • Igarashi et al.: NMN improved muscle motility, walking speed, grip strength, and chair-standing frequency in aged individuals.
   • Liao et al.: NMN enhanced aerobic capacity in trained runners.
   • Huang et al.: NMN promoted sustained walking endurance in middle-aged and older adults.
4. Metabolic Benefits:
   • NMN improved muscle insulin sensitivity by about 25% in postmenopausal women with prediabetes.
5. Age-Related Hearing Loss:
   • NMN supplementation improved hearing capabilities in older men.
6. Telomere Lengthening:
   • NMN nearly doubled telomere lengths in blood cells within 90 days of treatment in men aged 40 to 60 years, suggesting an anti-aging effect.

A number of rodent studies have shown that NMN improves brain, respiratory system, liver, heart, immune, and reproductive function, yet whether these benefits translate to humans remains to be determined. Essentially, more human trials are needed to find whether NMN confers the same benefits in humans as it does in rodents.

Finding Whether NMN Beneficially Affects Multiple Human Organ Systems During Aging

Nicotinamide mononucleotide (NMN), a precursor to nicotinamide adenine dinucleotide (NAD+), has shown promise in human trials. It improves physical function, metabolism, telomere length, and possibly hearing capabilities during aging. While studies suggest NMN is safe, questions remain about its long-term effects and whether it confers similar benefits across multiple organ systems as observed in rodents. Despite FDA restrictions, NMN’s safety profile and anti-aging potential warrant ongoing research.